Curcumin‐Derived Turn‐Off Fluorescent Probe for Copper (II) Ion Detection and Live Cell Imaging Applications

A curcumin-derived chemosensor 4,4'-((1E,3Z,5Z,6E)-3,5-bis((2hydroxyphenyl)imino) hepta-1,6-diene-1,7-diyl)bis(2-methoxyphenol) (HIBMP) was developed from curcumin and o-aminophenol using Schiff base condensation method. HIBMP selectively recognizes Cu (II) ion (Cu (II)) relative to other tested metal ions. Selective binding of Cu (II) ion turns off the fluorescent property of HIBMP and shows no interference with other metal ions. Moreover, the favourable binding of Cu (II) with HIBMP was noticed by a good linearity between the fluorescence intensity and concentration of Cu (II) with a range of 0-15.6 × 10