Liquid Polycaprolactone (PCL) for Reversing PXE's Skin Laxity of Inner Thighs and Knees: A Case Report

ABSTRACT Background/Aim Pseudoxanthoma elasticum (PXE) is a genetic connective tissue disorder that affects the skin with limited treatment options. A recent technology employing particle‐free polycaprolactone (PCL) has shown promising results in treating inner thighs and kness of a 27‐year‐old female patient. This article provides a case report along with our detailed treatment protocol based on the efficacy of PCL in reversing skin laxity that can be easily incorporated into the therapeutic approaches for patients with PXE. Methods The pinch test for clinical assessment, photographic documentation as well as satisfaction questionnaire were used in order to evaluate the improvement observed in skin laxity. Results After the finish of the protocol, the Pinch test score was diminished from 4 to 2, and the depth of the wrinkles was obviously improved in the photos. All the above, together with the high score of the patient satisfaction questionnaire, verified the efficacy of this novel PCL protocol in reversing PXE‘s skin laxity. Conclusion Fully liquid PCL appears to outperform other bio‐stimulators in improving skin quality in PXE, offering longer‐lasting results and a high safety profile. However, further clinical trials with long‐term follow‐up are required to confirm its efficacy in PXE‘s skin laxity.