Organocatalytic enantioselective [2 + 2] cycloadditions towards chiral fused α-trifluoromethyl azetidines

Herein, we report straightforward access to chiral fused α-trifluoromethyl azetidines via organocatalytic asymmetric [2 + 2] cycloadditions. This method is characterized by mild reaction conditions, high efficiency, and excellent stereoselectivities.