多巴胺
代谢物
高香草酸
体内
3,4-二羟基苯乙酸
神经递质
中枢神经系统
神经科学
药理学
生物
化学
医学
内科学
生物技术
受体
血清素
作者
Kaiyong Zou,Qianming Li,Dan Li,Yiding Jiao,Lie Wang,Luhe Li,Yuandong Wang,Yiran Li,Rui Gao,Fangyan Li,Er He,Tingting Ye,Wentao Tang,Jie Song,Jinhua Lu,X.-G. Li,Hanting Zhang,Xiaodan Cao,Ye Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-02-28
标识
DOI:10.1021/acsnano.3c11641
摘要
Homovanillic acid (HVA) is a major dopamine metabolite, and blood HVA is considered as central nervous system (CNS) dopamine biomarker, which reflects the progression of dopamine-associated CNS diseases and the behavioral response to therapeutic drugs. However, facing blood various active substances interference, particularly structurally similar catecholamines and their metabolites, real-time and accurate monitoring of blood HVA remains a challenge. Herein, a highly selective implantable electrochemical fiber sensor based on a molecularly imprinted polymer is reported to accurately monitor HVA in vivo. The sensor exhibits high selectivity, with a response intensity to HVA 12.6 times greater than that of catecholamines and their metabolites, achieving 97.8% accuracy in vivo. The sensor injected into the rat caudal vein tracked the real-time changes of blood HVA, which paralleled the brain dopamine fluctuations and indicated the behavioral response to dopamine increase. This study provides a universal design strategy for improving the selectivity of implantable electrochemical sensors.
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