巨噬细胞极化
微泡
细胞生物学
生物
肿瘤微环境
肿瘤进展
血管生成
免疫系统
小RNA
信号转导
细胞信号
外体
巨噬细胞
癌症研究
免疫学
癌症
体外
遗传学
基因
作者
Min Yao,Xuhua Mao,Zherui Zhang,Feilun Cui,Shihe Shao,Boneng Mao
标识
DOI:10.3389/fcell.2024.1289538
摘要
Non-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and regulation of immune cells. In macrophages, they stimulate the polarization of macrophages into M1 or M2 by regulating proteins related to signaling pathways; in tumor cells, non-coding RNAs can enter macrophages through exosomes and affect the latter polarization. The polarization of macrophages further regulates the biological functions of cancer cells. The direction of macrophage polarization determines tumor progression, angiogenesis and drug resistance. This often creates a feedback loop. Non-coding RNAs act as bridges between tumor cells and macrophages to regulate the balance of the tumor microenvironment. We reviewed the signaling pathways related to macrophage polarization and the regulatory mechanisms of non-coding RNA in tumor-associated macrophages M1 and M2, and discussed the potential applications and prospects of exosome engineering.
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