Insights into the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-induced gelation of fully carboxylated collagen and the fabrication of hydrogels with enhanced mechanical properties

EDC-induced gelation of succinylated collagen with a high concentration was realized, and its triple helix structure is crucial for this process. G′ of succinylated collagen hydrogel was improved to 310 Pa compared to 20 Pa of the collagen hydrogel.