转录组
肌萎缩
钥匙(锁)
鉴定(生物学)
心理干预
基因
计算生物学
阻力训练
生物信息学
生物
医学
遗传学
基因表达
内分泌学
生态学
护理部
作者
Lunyu Li,Xiaotian Guan,Shuai Zhang,Bo Qin,Binyu Yao,Lunyu Li
标识
DOI:10.1016/j.smhs.2024.01.005
摘要
We examined the effects of resistance and aerobic exercise on the gene expression and biometabolic processes of aging skeletal muscle in senescence-accelerated mouse/prone 8 mice, a model of sarcopenia, and compared them with senescence-accelerated mouse/resistant 1 mice acting as controls. We found that exercise improved muscle strength, endurance, fiber size, also modulated genes and pathways related to synaptic transmission, potassium transport, JAK-STAT signaling, and PI3K-Akt signaling. Our results suggested that BDNF, JAK2, RhoC, Myh6, Stat5a, Tnnc1, and other genes may mediate the beneficial effects of exercise on sarcopenia through these pathways.
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