长寿
代谢组学
队列研究
老年学
医学
比例危险模型
疾病
预期寿命
内科学
生理学
生物信息学
生物
人口
环境卫生
作者
Anne‐Julie Tessier,Fenglei Wang,Liming Liang,Clemens Wittenbecher,Danielle E. Haslam,A. Heather Eliassen,Deirdre K. Tobias,Jun Li,Oana A. Zeleznik,Alberto Ascherio,Qi Sun,Meir J. Stampfer,Francine Grodstein,Kathryn M. Rexrode,JoAnn E. Manson,Raji Balasubramanian,Clary B. Clish,Miguel A. Martínez‐González,Jorge E. Chavarro,Frank B. Hu,Marta Guasch‐Ferré
出处
期刊:Med
[Elsevier]
日期:2024-03-01
卷期号:5 (3): 224-238.e5
标识
DOI:10.1016/j.medj.2024.01.010
摘要
Summary
Background
A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods
In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings:
The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions
This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding
This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.
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