戒指(化学)
化学
环加成
催化作用
对映选择合成
组合化学
反应性(心理学)
有机化学
医学
替代医学
病理
作者
Amit Singh Adhikari,Nilanjana Majumdar
标识
DOI:10.1002/ejoc.202301225
摘要
Abstract Vinylcyclopropanes (VCPs) are important building blocks with multifaceted reactivity. Catalytic asymmetric ring opening of vinylcyclopropanes is a highly efficient process to access valuable chiral molecules with diverse functionalities that can be further functionalized for a series of synthetic purposes. VCPs are very well‐known substrates for cycloaddition reactions and this chemistry has been widely explored. On the contrary, despite of enormous synthetic potential, development of new innovative strategies for the catalytic, asymmetric ring opening of VCPs is somewhat underdeveloped. Recently, several significant examples have emerged in the literature for various asymmetric ring opening of both activated and unactivated vinylcyclopropanes that involve transition metal catalysis. These developments are relevant additions to the vinylcyclopropane chemistry. In this review, we aim to summarize all the catalytic asymmetric ring opening transformations reported till date and provide a comprehensive analysis of these research outcomes.
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