Rapid, Room-Temperature Amidation via Tandem Titanium Amido Complex and Titanium Carboxylate Intermediates

Titanium amido complexes are generated in situ from titanium tetrachloride. Subsequent reactions of these complexes with carboxylic acids generate activated titanium carboxylates which undergo amidation rapidly at room temperature. Spectroscopic studies and control reactions support the proposed mechanism and highlight the synthetic potential of this methodology.