Holistic Overview of the Phytoconstituents and Pharmacological Activities of Egyptian Riverhemp [ Sesbania sesban (L.) Merr.]: A Review

Background: Sesbania sesban (L.) Merr. (Family: Fabaceae), commonly known as Egyptian riverhemp, is a well-known plant widely distributed through Egypt, the rest of Africa and Asia. S. sesban leaves have been traditionally used as an anthelmintic, demulcent, purgative, and anti-inflammatory agent in the treatment of eczema, in addition to its agricultural uses. Objective: The aim of this review is to present a comprehensive account of the isolated constituents from S. sesban leaves, along with the correlation between those constituents and the reported biological activities. Methods: This search was performed using SciFinder, Google, Google Scholar, and CrossRef websites using the following keywords: “ Sesbania sesban,” “ Sesbania aegyptiaca,” “Egyptian riverhemp,” “phytochemistry,” “phytochemical constituents,” “isolation,” “steroids,” “triterpenoids,” “saponins,” “coumarins,” “lipoidal contents,” “pharmacological properties,” “biological activities,” “therapeutic uses,” and “review.” Results: S. sesban leaves exhibited several therapeutic potentials such as antioxidant, antimicrobial, antiviral, anthelmintic, molluscicidal, antifertility, anti-inflammatory, antidiabetic, antihyperlipidemic, anticancer, antianxiety, and mosquito repellant properties. An updated chemical study of S. sesban leaves has provided a variety of essential metabolites belonging to different chemical classes including steroids, triterpenoids, saponins, flavonoids, coumarins, lipids, and other miscellaneous compounds. The correlations between biological activities and phytoconstituents are discussed. Conclusion: This article represents an updated comprehensive evaluation of the phytochemical and biological studies of S. sesban leaves.