有机催化
有机化学
立体中心
迈克尔反应
金鸡纳生物碱
对映体
作者
Siming Jia,Mengmeng Ma,Erqing Li,Zheng Duan,Françis Mathey
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-04-14
卷期号:23 (9): 3337-3342
被引量:3
标识
DOI:10.1021/acs.orglett.1c00833
摘要
Two novel diastereoisomeric P-chirogenic phosphine catalysts, i.e., JiaPhos, which can be easily derived from inexpensive and commercially available starting materials in five chemical operations (totally 4.16g scale), are introduced. To our delight, the JiaPhos catalysts display good performance in enantioselective (4 + 2) annulations involving 3-methylene-2-oxindoles and γ-benzyl allenoates, providing a wide range of 3,3'-spirocyclic oxindoles with good efficiency and enantioselectivity.
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