光动力疗法
单线态氧
赫拉
光化学
荧光
聚合物
合理设计
乙二醇
化学
纳米技术
材料科学
组合化学
氧气
有机化学
物理
细胞
量子力学
生物化学
作者
Xiaoxiao Hu,Qiang Zhang,Xiaomei Dai,Junyong Sun,Feng Gao
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2021-09-24
卷期号:4 (10): 7663-7672
被引量:13
标识
DOI:10.1021/acsabm.1c00892
摘要
The pH environment in cancer cells has been demonstrated to display vital influences on the therapeutic effect of photodynamic therapy (PDT). It is very interesting to develop pH-responsive probes for simultaneous pH sensing and dynamics monitoring of the effects of PDT, and therefore assessing the correlation between them. In this study, a multifunctional fluorescence probe, dual-emission carbonized polymer dot (CPD) in blue and red regions, which uses ethylene imine polymer (PEI) and 4,4',4″,4‴-(porphine-5, 10, 15, 20-tetrayl) tetrakis (benzoic acid) (TCPP) as precursors through a one-step hydrothermal amide reaction, has been designed for ratiometric pH sensing, generating pH-dependent 1O2 for PDT of cancer cells, and investigating the dynamics effects of PDT through pH-guided imaging. The prepared CPDs were successfully used for ratiometric pH response, pH-dependent generation of 1O2, and dynamics monitoring PDT in HeLa cells. This study may provide an alternative strategy to prepare CPD-based theranostic integrated nanoprobes for PDT through the rational design of precursors.
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