程序性细胞死亡
细胞生物学
人类健康
GPX4
生物
氧化应激
细胞凋亡
遗传学
生物化学
医学
环境卫生
谷胱甘肽过氧化物酶
过氧化氢酶
作者
Jing Lü,Yanan Zhao,Meitong Liu,Jianing Lu,Shuang Guan
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2021-01-01
卷期号:12 (20): 9583-9606
被引量:44
摘要
Ferroptosis is a recently defined type of regulated cell death caused by an excess iron-dependent accumulation of lipid peroxides and is morphologically and biochemically distinct from other types of cell death. Notably, Nrf2 is identified to exquisitely modulate ferroptosis due to its ability to target a host of ferroptosis cascade genes, which places Nrf2 in the pivotal position of ferroptosis. This paper reviews the regulation effect of Nrf2 on ferroptosis, different activation mechanisms of Nrf2 as well as the relevance of the Nrf2-ferroptosis axis in diseases, and finally summarizes foods with beneficial effects in ferroptosis via the Nrf2 pathway and aims to serve as a reference for follow-up studies of food functions related to Nrf2, ferroptosis, and human health.
科研通智能强力驱动
Strongly Powered by AbleSci AI