Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using So-dium Tripolyphosphate in Water

Abstract: An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpy-rimidines. The reaction of pyrimidine phosphonium ylide with different aryl/hetero-aryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).