血脂异常
医学
阻塞性睡眠呼吸暂停
混淆
睡眠呼吸暂停
糖尿病
机制(生物学)
内科学
疾病
肥胖
重症监护医学
流行病学
风险因素
缺氧(环境)
心脏病学
生物信息学
内分泌学
生物
有机化学
化学
哲学
氧气
认识论
作者
Ajibola Monsur Adedayo,Oladipupo Olafiranye,David S. Smith,Alethea N. Hill,Ferdinand Zizi,Clinton D. Brown,Girardin Jean-Louis
标识
DOI:10.1007/s11325-012-0760-9
摘要
Over the past half century, evidence has been accumulating on the emergence of obstructive sleep apnea (OSA), the most prevalent sleep-disordered breathing, as a major risk factor for cardiovascular disease. A significant body of research has been focused on elucidating the complex interplay between OSA and cardiovascular risk factors, including dyslipidemia, obesity, hypertension, and diabetes mellitus that portend increased morbidity and mortality in susceptible individuals.Although a clear causal relationship of OSA and dyslipidemia is yet to be demonstrated, there is increasing evidence that chronic intermittent hypoxia, a major component of OSA, is independently associated and possibly the root cause of the dyslipidemia via the generation of stearoyl-coenzyme A desaturase-1 and reactive oxygen species, peroxidation of lipids, and sympathetic system dysfunction. The aim of this review is to highlight the relationship between OSA and dyslipidemia in the development of atherosclerosis and present the pathophysiologic mechanisms linking its association to clinical disease. Issues relating to epidemiology, confounding factors, significant gaps in research and future directions are also discussed.
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