血管生成素受体
背景(考古学)
恶性肿瘤
癌症研究
血管生成
医学
受体
生物
神经科学
病理
内科学
古生物学
作者
Hanhua Huang,Abhijit Bhat,Gary Woodnutt,Rodney W. Lappe
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2010-08-01
卷期号:10 (8): 575-585
被引量:389
摘要
Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT-TIE system are context dependent, which brings into question what the best strategy is to target this pathway. This Review presents an encompassing picture of what we know about this important axis in tumour biology. The various options for therapeutic intervention are discussed to identify the best path forwards.
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