化学
白杨素
电喷雾电离
电喷雾
质谱法
非共价相互作用
光谱学
生物物理学
色谱法
生物化学
分子
有机化学
氢键
类黄酮
抗氧化剂
物理
量子力学
生物
作者
Xiaolan Chen,Lingbo Qu,Ting Zhang,Hongxia Liu,Fei Yu,Youzhu Yu,Xincheng Liao,Yufen Zhao
摘要
In the work described in this paper, chrysin was phosphorylated by a modified Atheron-Todd reaction. The structure of phosphorylated chrysin was determined by elemental analysis, NMR, ESI-MS/MS, and X-ray data. Electrospray ionization results showed that the phosphorylated flavonoids could form noncovalent complexes with many proteins, such as lysozyme, myoglobin, bovine insulin, and cytochrome c, while noncovalent complexes were not detected in the mixed solution of the chrysin and proteins. The research shows that the phosphorylated flavonoids possess relatively stronger affinities and form noncovalent complexes with the proteins more easily than the non-phosphorylated compounds.
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