明胶
自愈水凝胶
微流控
组织工程
材料科学
纳米技术
制作
生物医学工程
化学
高分子化学
工程类
生物化学
医学
病理
替代医学
作者
Andrew Golden,Joe Tien
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2007-01-01
卷期号:7 (6): 720-720
被引量:441
摘要
This paper describes a general procedure for the formation of hydrogels that contain microfluidic networks. In this procedure, micromolded meshes of gelatin served as sacrificial materials. Encapsulation of gelatin meshes in a hydrogel and subsequent melting and flushing of the gelatin left behind interconnected channels in the hydrogel. The channels were as narrow as approximately 6 microm, and faithfully replicated the features in the original gelatin mesh. Fifty micrometre wide microfluidic networks in collagen and fibrin readily enabled delivery of macromolecules and particles into the channels and transport of macromolecules from channels into the bulk of the gels. Microfluidic gels were also suitable as scaffolds for cell culture, and could be seeded by human microvascular endothelial cells to form rudimentary endothelial networks for potential use in tissue engineering.
科研通智能强力驱动
Strongly Powered by AbleSci AI