绒毛
毛乳头
毛囊
脱发
多毛症
医学
内分泌学
卡贝洛
内科学
头皮
阴毛
雄激素
皮肤病科
激素
胰岛素
胰岛素抵抗
多囊卵巢
标识
DOI:10.1111/j.1529-8019.2008.00214.x
摘要
ABSTRACT: Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and terminal follicles making bigger, pigmented hairs. The response to androgens varies with the body site as it is specific to the hair follicle itself. Normally around puberty, androgens stimulate axillary and pubic hair in both sexes, plus the beard, etc. in men, while later they may also inhibit scalp hair growth causing androgenetic alopecia. Androgens act within the follicle to alter the mesenchyme–epithelial cell interactions, changing the length of time the hair is growing, the dermal papilla size and dermal papilla cell, keratinocyte and melanocyte activity. Greater understanding of the mechanisms of androgen action in follicles should improve therapies for poorly controlled hair disorders like hirsutism and alopecia.
科研通智能强力驱动
Strongly Powered by AbleSci AI