皮克林乳液
渗透
角质层
乳状液
化学
色谱法
化学工程
吸收(声学)
吸附
材料科学
膜
有机化学
复合材料
生物化学
医学
病理
工程类
作者
J. Frelichowska,Marie‐Alexandrine Bolzinger,Jean‐Pierre Valour,H. Mouaziz,Jocelyne Pelletier,Yves Chevalier
标识
DOI:10.1016/j.ijpharm.2008.09.057
摘要
The skin absorption from Pickering emulsions as a new dosage form was investigated for the first time. Pickering emulsions are stabilized by adsorbed solid particles instead of emulsifier molecules. They are promising dosage forms that significantly differ from classical emulsions within several features. The skin permeation of a hydrophilic model penetrant (caffeine) was investigated from a w/o Pickering emulsion and compared to a w/o classical emulsion stabilized with an emulsifier. Both emulsions had the same composition and physicochemical properties in order to focus on the effect of the interfacial layer on the drug release and skin absorption processes. The highest permeation rates were obtained from the Pickering emulsion with a pseudo-steady state flux of 25 μg cm−2 h−1, threefold higher than from a classical emulsion (9.7 μg cm−2 h−1). After 24 h exposure, caffeine was mostly in the receptor fluid and in the dermis; cumulated amounts of caffeine were higher for the Pickering emulsion. Several physicochemical phenomena were investigated for clearing up the mechanisms of enhanced permeation from the Pickering emulsion. Among them, higher adhesion of Pickering emulsion droplets to skin surface was disclosed. The transport of caffeine adsorbed on silica particles was also considered relevant since skin stripping showed that aggregates of silica particles entered deeply the stratum corneum.
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