PTEN公司
自噬
PI3K/AKT/mTOR通路
雌激素受体
蛋白激酶B
细胞生物学
雌激素受体
受体
雌激素
化学
信使核糖核酸
信号转导
生物
内分泌学
基因
细胞凋亡
生物化学
遗传学
癌症
乳腺癌
作者
Mei Zeng,Baofeng Chen,Yufeng Qing,Wei Xie,Wantai Dang,Mingqiu Zhao,Jingguo Zhou
标识
DOI:10.1080/15257770.2014.885045
摘要
Glut9 is highly expressed in the human kidney proximal convoluted tubular and plays a crucial role in the regulation of plasma urate levels. The gene effects were stronger among women. Our results show that 17-β-estradiol (E2) through ER (estrogen receptor) β downregulates Glut9 protein expression on human renal tubular epithelial cell line (HK2). Intriguingly, E2 does not affect the expression of Glut9 mRNA. ERβ is linked to PTEN, the PTEN gene negatively regulates the PI3K/AKT pathway, and the PI3K/AKT pathway inhibition may lead to autophagy. Further study indicates that ERβ may affect the expression of Glut9 though autophagy.
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