海马体
神经科学
海马结构
内嗅皮质
鼻周皮质
心理学
背景(考古学)
扁桃形结构
光遗传学
情景记忆
识别记忆
颞叶
脾后皮质
助记符
召回
工作记忆
认知心理学
认知
生物
癫痫
古生物学
作者
Kazumasa Tanaka,Aleksandr Pevzner,Anahita B. Hamidi,Yuki Nakazawa,Jalina Graham,Brian J. Wiltgen
出处
期刊:Neuron
[Elsevier]
日期:2014-10-22
卷期号:84 (2): 347-354
被引量:277
标识
DOI:10.1016/j.neuron.2014.09.037
摘要
The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this idea, we monitored the activity of individual cortical neurons while simultaneously inactivating the hippocampus. Neurons that were active during context fear conditioning were tagged with the long-lasting fluorescent protein H2B-GFP and the light-activated proton pump ArchT. These proteins allowed us to identify encoding neurons several days after learning and silence them with laser stimulation. When tagged CA1 cells were silenced, we found that memory retrieval was impaired and representations in the cortex (entorhinal, retrosplenial, perirhinal) and the amygdala could not be reactivated. Importantly, hippocampal inactivation did not alter the total amount of activity in most brain regions. Instead, it selectively prevented neurons that were active during learning from being reactivated during retrieval. These data provide functional evidence that the hippocampus reactivates specific memory representations during retrieval.
科研通智能强力驱动
Strongly Powered by AbleSci AI