Glabridin-loaded PCL/silk fibroin core–shell nanofibers with immunomodulatory and antioxidant activities for cutaneous wound healing

, PGS scaffolds markedly accelerated skin tissue reconstruction and promoted regeneration of cutaneous appendages, including hair follicles and sweat glands. In conclusion, through rational core-shell design, this study integrates antioxidant and immunomodulatory functions within a single coaxially electrospun scaffold, offering a clinically translatable strategy for chronic diabetic wound repair and the comprehensive structural and functional reconstruction of skin tissue.