先天免疫系统
免疫学
效应器
免疫
获得性免疫系统
生物
乙型肝炎病毒
发病机制
病毒学
病毒
免疫系统
作者
Mala K. Maini,Adam J. Gehring
标识
DOI:10.1016/j.jhep.2016.01.028
摘要
In this review we give a brief update on sensors recently determined to be capable of detecting HBV, and examine how the virus represses the induction of pro-inflammatory cytokines like type I interferons. We overview cellular components of innate immunity that are present at high frequencies in the liver, and discuss their roles in HBV control and/or pathogenesis. We argue that many innate effectors have adaptive-like features or can exert specific effects on HBV through immunoregulation of T cells. Finally we consider current and possible future strategies to manipulate innate immunity as novel approaches towards a functional cure for HBV.
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