Observation of rat colorectal cancer model induced by dimethylhydrazine

Objective To establish colorectal cancer animal model and provide experimental basis for human colorectal cancer research.Method Using dimethylhydrazine to induce Wistar rat colorectal cancer and killed them at 12,18,and 24 weeks after treated,the colorectal mucosa pathological changes of different experiment and control groups were observed.Results During the carcinogensis process,the light,medium and heavy atypical hyperplasia were observed.At 12 weeks,none cancer was observed in experimental groups.At 18 weeks,the incidence of tumor and colorectal cancer were 60% and 50% respectively.At 24 weeks,the incidence of tumor and colorectal cancer were 100% and 80% respectively.Conclusions The incidence of rat colon cancer model induced by dimethylhydrazine were high,the development of which was similar to the human colorectal cancer.The model can be used for the experimental study of human colorectal cancer.