Meta analysis on the association between children 5,10-methlennetrahydrofolate reducates C677T polymorphism and the neural tube defects of their offspring

Objective Methylenetetrahydrofolate reductase(MTHFR) polymorphism C667T has been associated with the neural tube defects(NTDs),this common missense mutation in the MTHFR gene may reduce enzymatic action,and may be involved in the neural tube defects.The aim of this study was to investigate the relationship of the MTHFR C677T polymorphism with the neural tube defects.Methods Electronic search strategy was carried out among the five databases from home and abroad to collect qualified research papers,according to the inclusion and exclusion criteria.Case-control studies on association between MTHFR polymorphism and susceptibility to NTDs were collected.The combined OR values and their 95%C1 were calculated using STATA 7.0.Results Nine eligible studies were included.Statistics of the combined data showed a significant difference between the children NTDs offspring carrying TT/CC,CT+TT/CC and TT/CT+TT of MTHFR gene C677T and controls.The pooled OR(95%CI)were 1.78(1.12 ~2.81),1.28(1.07~1.55) and 1.73(1.07~2.78)respectively.Conclusion The results suggested that the children's MTHFR gene C677T polymorphism were risk factors to NTDs.