肺部给药用高分子多孔微球的生物学评价研究进展

As a non-invasive administration method, inhalable pulmonary drug delivery is suitable for the delivery of protein- and peptide-based drugs to treat lung diseases. Porous polymeric microspheres, which possess low mass densities(0.4 g/cm3) and large mean geometric diameters(10.0 μm), provide local or systemic drug delivery as they are deposited directly in the lung, and the uptake by alveolar macrophages is reduced. As inhalable drug carriers, porous polymeric microspheres should be biocompatible and offer in vitro drug-release properties. We review the progress in biological evaluation of these microspheres and propose solutions for the current problems. The biocompatibility evaluation of porous polymeric microspheres has been summarized at cellular, integrated and molecular levels. The medical function evaluation has been conducted on lung deposition, clearance and absorption within the lung and pharmacodynamics of drug loaded porous polymeric microspheres.