Objective To summarize the clinical methods and effectiveness of percutaneous vertebroplaty.Methods Tweenty-two cases(25 vertebral bodies) with Osteoporotic vertebral compression fractures and vertebral tumors were treated by percutaneous vertebroplaty from August 2005 to August 2008.3~5 mL bone cement was injected after the puncture needle was inserted into the fractured vertebal body transpedicularly under C arm imaging guiding.Results Pain relieved of all patients was significantly different(P0.01) according to the VAS scale as compared with postoperation in the following day,the patients were allowed to get off bed.There was 1 patient with a small quantities of paravertebral leavages with no symptoms.Another patient had unknown psychological symptom,he was treated in psychological department and was discharged after 1 week with no symptons.Conclusions The techonical difficulty of percutaneous vertebroplaty is accurate accupuncture and in controle of timing of bone cement injection.The percutaneous vertebroplaty has wider applied future for cure of spinal diseases with the development of PVP and new type of fillings.