Determination of Concentration of Carbamazepine in Human Plasma by HPLC

Objective To establish a rapid, convenient and accurate method to determine the concentration of car-bamazepine in human plasma. Methods The concentration of carbamazepine was determined by RP-HPLC. Results The linearity range was 0.4-25μg/ml with a regressive equation of Y= 12.5X + 0.142 5, r = 0.996 0. The recovery rate was 97.5 % . RSD was 1.5% (intra-day) and 2.3% (inter-day) . Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.