OBJECTIVE In order to prepare high purity of salidroside,reduce production cost, in this paper,w e studied new method for chemosynthesis of salidroside. METHODS To get salidroside,this experiment w ith the hydroxy benzene ethanol as raw material by glycosidic reaction. RESULTS By high performance liquid chromatography( HPLC) testing,the purity of salidroside is 98. 5%. CONCLUSION The experimental method can prepare high purity rhodiola glucoside and reduce production cost,and provide certain reference for the industrialized production of high purity salidroside.