Pancreatic encephalopathy(PE)is a severe complication of severe acute pancreatitis,which is characterized by a group of neurological signs and symptoms.It′s difficult to have an early diagnosis of PE.The mortality of PE is high and the prognosis is very bad.Eliminating various inducements,early diagnosis and combined therapy are the keys to achieve better efficacy in the treatment of PE.This paper reviews the roles of pamcreatin,electrolyte disturbances,hypoxemia,affectoi and vitamin deficiency in the pathogenesis of PE,also,the clinical manifestation,diagnosis and treatment of PE are summarized with the view to get further understand of PE.