Objective To observe the efficacy of the knee joint injection of sodium hyaluronate on knee osteoarthritis. Methods 112 outpatients and inpatients with knee osteoarthritis who were given the intra-articular injection of sodium hyaluronate from September 1998 to August 2010 were summarized,20 mg sodium hyaluronate was injected in intra-articular,one time for one week. The curative effect was evaluated after continuous injection for 5 weeks. Lyshlom knee joint function score before surgery was(64.8 ± 3.0) . Through the follow-up of 6 months to 5 years,the patients' self-evaluation,squatting activities and movement pain,joint swelling,limps,support,knee range of motion and other clinical manifestations were observed. Results After the treatment,knee joint function improved significantly,Lyshlom knee joint function score was(90.0 ± 1.4) . The excellent and good rate was 91.96%. Conclusion Intra-articular injection of sodium hyaluronate can significantly reduce the local symptoms of knee joint,and increase joint activity and restore knee joint function.