The Post-receptor Signal Transduction Mechanism of the Expression of GTH

It is an important area of research on the mechanism of gonadotropin-releasing hormone.The paper reviews the domestic and foreign advances on GnRH and think GnRH regulates the synthesis and secretion of FSH and LH after binding its receptor in a series of signal transduction.The GnRH post-receptor signal transduction pathway may consist of three major signal transduction system : the cAMP signal transduction system,PKC signal transduction system and MAPK signal transduction system.cAMP signal transduction pathway and PKC signal transduction pathway belong to G protein coupling signaling pathways,who both finish regulation by activating MAPK signal transduction system at last.It provides the base on the further study,some suggestions gived on existents problems and further research direction raised.