萧条(经济学)
神经科学
心理学
免疫系统
心情
抑郁症动物模型
情绪障碍
脆弱性(计算)
中枢神经系统
精神科
医学
焦虑
抗抑郁药
海马体
免疫学
计算机科学
宏观经济学
经济
计算机安全
作者
Georgia E. Hodes,Veronika Kana,Caroline Ménard,Miriam Mérad,Scott J. Russo
摘要
Current diagnosis of depression is based solely on behavioral symptomatology. The available US Food and Drug Administration-approved treatments for depression have come from serendipitous discovery and are ineffective in nearly 30-50% of patients, which is thought to reflect a lack of specificity in targeting underlying pathophysiological mechanisms. Recent evidence has identified depression-related disruptions in a neuroimmune axis that interfaces the immune system and CNS to control behavior. This Review examines the evidence in patients and in animal models of depression that demonstrates how the peripheral immune system acts on the brain to alter an individual's response to stress, ultimately contributing to their vulnerability to mood disorders.
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