光热治疗
纳米棒
光动力疗法
表面等离子共振
生物相容性
吲哚青绿
纳米技术
光热效应
材料科学
光敏剂
胶体金
激光器
纳米颗粒
化学
生物医学工程
体内
医学
外科
冶金
有机化学
作者
Beilei Gong,Yuanbing Shen,Huiyan Li,Xiaojun Li,Xia Huan,Ji-hong Zhou,Yuqing Chen,Jian Wu,Wei Li
标识
DOI:10.1186/s12951-020-00754-8
摘要
Abstract Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In this study, a new nanoplatform of thermo-responsive polymer encapsulated gold nanorods incorporating indocyanine green (ICG) was designed to couple the photothermal properties of gold nanorods (AuNRs) and the photodynamic properties of ICG to enhance the photodynamic/photothermal combination therapy (PDT/PTT). In addition to the significantly increased payload and enhancing photostability of ICG, the polymer shell in the nanoplatform also has thermo-responsive characteristics that can control the release of drugs at tumour sites upon the laser irradiation. On the basis of these improvements, the nanoplatform strongly increased drug aggregation at the tumour site and improved the photothermal/photodynamic therapeutic efficacy. These results suggest that this nanoplatform would be a great potential system for tumour imaging and antitumour therapy.
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