骨关节炎
医学
软骨
生物标志物
滑液
疾病
透明软骨
生物信息学
病理
重症监护医学
关节软骨
替代医学
生物
生物化学
解剖
作者
Silvia Ravalli,Marta Anna Szychlinska,Giovanni Lauretta,Michelino Di Rosa,Giuseppe Musumeci
标识
DOI:10.1080/14737159.2020.1733978
摘要
Introduction: Osteoarthritis (OA) is a degenerative disease which primarily affects hyaline cartilage, leading to pain, stiffness and loss of mobility of the entire articulation. Diagnosis is commonly based on symptoms and radiographs, but there is a growing interest in detecting novel biomarkers, in serum, urine and synovial fluid, which can be predictors of disease onset and progression.Areas covered: This review provides an overview of the main biomarkers currently used in OA clinical practice, with a focus on lubricin, a surface glycoprotein secreted in the synovial fluid that lubricates the cartilage and reduces the coefficient of friction within the joint. Key findings of the last years are presented throughout the article.Expert opinion: Analysis of biomarkers might suggest personalized protocols of treatment, guide the classification of OA phenotypes, contribute to precision medicine, avoid further unnecessary exams, facilitate drug discovery or refine treatment guidelines. For all these reasons, the investigation of novel cartilage-based biomarker of osteoarthritis needs to be promoted and improved.
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