Application of US EPA IRIS systematic review methods to the health effects of phthalates: Lessons learned and path forward

This special issue presents several systematic reviews of the potential human health effects associated with exposure to phthalates and addresses some of the considerations and challenges that were encountered over the course of performing these reviews. This editorial presents the views of the lead U.S. Environmental Protection Agency (EPA) researchers on the project and the Special Issue Editors with regard to lessons learned, implications of methods, and the path forward for systematic reviews to support human health assessment.