Bio-inspired nanochannels: fabrication, modification and bioanalytical applications

As a new technology, nanofluidics has received considerable interests. The generation and development of nanofluidics have been accompanied by the emergency of new fluidic phenomena and novel devices. The unique mass transport properties and potential applications in nanofluidics have attracted wide attention. To date, nanochannel devices have shown great application prospects in DNA sequencing, single molecule sensing, energy storage and conversion, and ionic gating. In this review, we systematically summarize the fabrication and modification of nanochannel membrane, and their applications in the bioanalysis. The developments and challenges of nanochannel membranes are also prospected.