Leflunomide combined with methotrexate in treatment of Rheumatoid Arthritis

Objective To explore the efficacy and safety of leflunomide combined with methotrexate in the treatment of rheumatoid arthritis.Methods 120 patients with active rheumatoid arthritis were randomly divided into a treatment group(n=60) and a control group(n=60).The treatment group was treated with leflunomide and methotrexate,while the control group with only methotrexate.The efficacies and adverse reactions compared between two groups.Results The total effective rate was 88.3％ in the treating group and was 71.7％ in the control group,with a statistical difference(P＜0.05).The incidence of adverse reactions was 25％ in the treating group and was 20％ in the control group,with no statistical difference (P＞0.05).Conclusion Leflunomide combined with methotrexate in the treatment of rheumatoid arthritis is effective and worth being clinically generalized. Key words: Rheumatoid arthritis;  Leflunomide;  Methotrexate