Meta analysis to evaluate the anticoagulant treatment after cerebral hemorrhage of venous thromboembolism prevention

Objective To evaluate the anticoagulant treatment after intra-cerebral hemorrhage of venous thromboembolism preventive effect and the safety.Methods Collecting the prevention of deep vein thrombosis anticoagulant therapy research of patients with cerebral hemorrhage in retrieval computer database MEDLINE,PubMed,Cochrane RCT,Embase,Biosis from 1966 years to 2010 years,including randomized controlled trials (RCT) and case control study.Three researchers have completed strict quality evaluation and literature data extraction,and have done Meta analysis in RCT and case control study according with the standard of quality.Results We absorbed 5 article of RCT and 2 article of case control study.Five randomized controlled studies have litter heterogeneity (I2 =0％,P ＞ 0.05 ) and show that compared with the control,anticoagulation drugs to deep vein thrombosis have preventive effect,but the difference was no statistically significant ( RR =0.68,Z =1.66,P ＞ O.05 ) ; Two case control study results can' t fully embody the anticoagulant utilized prevention function. Research results show that anticoagulation group and control group in intracranial hematoma enlargement or bleed again have no statistically significant differences.Conclusions Anticoagulation drugs in deep vein thrombosis prevention may have the effect,but the safety is lack of compelling evidence in current.So it was recommended for patients with cerebral hemorrhage of deep vein thrombosis,should be careful to use preventing anticoagulant in clinical,and utilized as far as possible target therapies. Key words: Cerebral hemorrhage; Venous thromboembolism; Anticoagulant treatment; Prevention; Meta analysis