Effects of oxycodone hydrochloride on the postoperative patient-controlled intravenous analgesia in gastric cancer patients undergoing laparoscopic radicalgastrectomy

Objective To investigate the effects of oxycodone hydrochloride on the postoperative patient-controlled intravenous analgesia (PCIA) in gastric cancer patients undergoing laparoscopic radical gastrectomy. Methods Fifty gastric cancer patients were enrolled and randomly divided into the two groups: group A (sufentanil group) and group B (oxycodone group), with 25 cases in each group. The included patients had ASA physical status I or II, and aged from 30 to 60 years old, weight ranged from 50 to 75 kg. All patients underwent general intraveneous anesthesia. Thirty minutes before the end of surgery, each patient in group A was injected intravenously with sufentanil 0.1 μg/kg, while oxycodone hydrochloride 0.1 mg/kg in group B. Both groups began to receive PCIA in PACU: group A: sufentanil 3 μg/kg+ normal saline 100 ml, group B: oxycodone hydrochloride 0.5 mg/kg+ saline 100 ml; parameter settings: the infusion rate of 2 ml/h, a single dose of 2 ml, lock time 15 minutes. And visual analogue scale (VAS) was performed to evaluate the dynamic pain, rest pain and visceral pain at 3, 6, 12, 24, and 48 h after operation. Meanwhile the incidences of nausea, vomiting and drowsiness were recorded in the recovery period and 48 h after operation. Results The spontaneous breathing recovery time, extubation time and recovery time was significantly shorter in group B than those in group A (P 0.05). The VAS scores of visceral pain in group B was significantly lower than that of group A (P<0.05). The incidences of postoperative nausea and vomiting and lethargy of group B were significantly lower than those of group A(P<0.05) in recovery period and 48 h after operation. Conclusions Oxycodone hydrochloride in laparoscopic radical gastrectomy for gastric cancer patients can effectively relieve the postoperative pain, and especially have better analgesic effect on visceral pain than sufentanil, and meanwhile the incidence of adverse reaction is lower than sufentanil. Key words: Oxycodone; Sufentanil; Patient-controlled intravenous analgesia; Postoperative pain; Laparoscopic surgery; Gastric cancer