银杏
神经保护
药理学
植物化学
医学
银杏
注意缺陷多动障碍
多巴胺
传统医学
化学
精神科
生药学
生物活性
生物化学
内科学
体外
作者
Garima Sharma,Naveen Sharma,Bao Trong Nguyen,Ji Hoon Jeong,Seung‐Yeol Nah,Yukio Yoneda,Eun‐Joo Shin,Hyoung‐Chun Kim
出处
期刊:Current Molecular Pharmacology
[Bentham Science]
日期:2020-12-31
卷期号:14 (2): 200-209
被引量:6
标识
DOI:10.2174/1874467213666200424152454
摘要
Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder commonly found in children, which is recognized by hyperactivity and aggressive behavior. It is known that the pathophysiology of ADHD is associated with neurobiological dysfunction. Although psychostimulants are recognized as the therapeutic drugs of choice for ADHD patients, the side effects might be of great concern. Ginkgo biloba is a promising herbal, complementary supplement that may modulate the neuronal system in an ADHD-like condition. The beneficial effect of Ginkgo biloba on ADHD-like symptoms may be related to the modulation of the system by novel molecular mechanisms. Ginkgo biloba is known to modulate dopamine, serotonin, and norepinephrine signaling. Flavonoid glycosides and terpene trilactones are the two major phytochemical components present in the Ginkgo biloba preparations, which can exhibit antioxidant and neuroprotective activities. The pharmacological mechanisms of the phytochemical components may also contribute to the neuroprotective activity of Ginkgo biloba. In this review, we have summarized recent findings on the potential of various Ginkgo biloba preparations to treat ADHD-like symptoms. In addition, we have discussed the pharmacological mechanisms mediated by Ginkgo biloba against an ADHD-like condition.
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