Synthesis of N1‐Substituted 1,2,3,6‐Tetrahydropyrimidin‐ 2‐ones via an Unexpected Reaction of Thiazolo[3,2‐a]‐pyrimidine Derivatives and Nitrile Oxide

Abstract A new class of N1‐substituted 1,2,3,6‐tetrahydropyrimidin‐2‐ones was prepared in moderate yields by the reaction of nitrile oxide with thiazolo[3,2‐a]pyrimidine derivatives via a domino 1,3‐dipolar cycloaddition/ring‐opening/ substitution process. The structures of the products were characterized thoroughly by IR, elemental analysis, MS, NMR together with X‐ray crystallographic analysis.