The sensing of mitochondrial DAMPs by non-immune cells

The sensing of mitochondrial DAMPs by non-immune cells – MITOCHONDRIA ARE IMMUNOGENIC ORGANELLES The efficiency of the innate immune system is determined by the capacity of distinct cell types to discriminate self from non-self structures. The dysregulation of this ability results in either immunodeficiency pathologies or autoinflammatory and autoimmune diseases. The immune system is primed to recognize pathogen-associated molecular patterns (PAMPs), derived from infection, through (...)