Systemic administration of α-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis

• Intravenous α-lipoic acid injection suppresses SpVc neuronal excitability. • Neuronal firing rates were dose-dependently inhibited by α-lipoic acid. • The inhibitory effect of α-lipoic acid lasted for 5–10 min and was reversible. • α-lipoic acid may be an effective treatment option for trigeminal pain. Although a modulatory role has been reported for α-lipoic acid (LA) on T-type Ca 2+ channels in the nervous system, the acute effects of LA in vivo , particularly on nociceptive transmission in the trigeminal system, remain to be determined. The aim of the present study was to investigate whether acute intravenous LA administration to rats attenuates the excitability of wide dynamic range (WDR) spinal trigeminal nucleus caudalis (SpVc) neurons in response to nociceptive and non-nociceptive mechanical stimulation in vivo . Extracellular single unit recordings were made from seventeen SpVc neurons in response to orofacial mechanical stimulation of pentobarbital-anesthetized rats. Responses to both non-noxious and noxious mechanical stimuli were analyzed in the present study. The mean firing frequency of SpVc WDR neurons in response to both non-noxious and noxious mechanical stimuli was significantly and dose-dependently inhibited by LA (1–100 mM, i.v.) and maximum inhibition of the discharge frequency of both non-noxious and noxious mechanical stimuli was seen within 5 min. These inhibitory effects lasted for approximately 10 min. These results suggest that acute intravenous LA administration suppresses trigeminal sensory transmission, including nociception, via possibly blocking T-type Ca 2+ channels. LA may be used as a therapeutic agent for the treatment of trigeminal nociceptive pain.