Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: Proportion and determinants of underreporting to pharmacovigilance

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immunologically mediated severe cutaneous adverse reactions (SCARs) secondary in most cases to the administration of a drug.1 Reporting to national pharmacovigilance databases is an important source of information on adverse drug reactions (ADRs). In France, health care professionals, including physicians and pharmacists, are legally required to report to pharmacovigilance all suspected ADRs. However, it has been estimated that only 5% to 15% of serious ADRs are reported to pharmacovigilance, even though very little accurate data are available.