Synthesis of Polydopamine Nanoparticles for Drug Delivery Applications

For decades, pharmaceutical sciences have been using nanoparticles for drug delivery in order to reduce toxicity and side effects of drugs. Therefore, biodegradable and biocompatible nanocarrier is essential to deliver the drug within the therapeutic window [1]. A wide range of nanoparticles have been developed so far as carriers of drugs and other biomolecules such as liposomes, dendrimers, polymeric nanoparticles, mesoporous silica etc.[2] However, such nanocarriers required complicated procedures and instrumentation for their synthesis and fabrication. Herein, we have reported the synthesis of polydopamine nanoparticles (PDA NPs) by using a very simple procedure without involving harsh reaction conditions and complicated instrumentation.