IgA Deposits Along Glomerular Basement Membranes in Rapidly Progressive Glomerulonephritis

This case presents a rare type of crescentic glomerulonephritis characterized as IgA deposits predominantly along the glomerular basement membranes (GBM). The patient clinically manifested with rapidly progressive glomerulonephritis (RPGN) without pulmonary hemorrhage or vasculitis-related systematic symptoms. No positive results were found on antinuclear antibody (ANA), antineutrophil cytoplasmic antibody (ANCA), or anti-GBM antibody detection. Therapy with pulse methylprednisolone and intravenous cyclophosphamide was less effective. This case does not belong to the present three categories of crescentic glomerulonephritis based on the clinical characteristics, serum test, immunofluorescence, and electron microscopic findings.