Summary. This study was aimed at assessment of quality of life in hospitalized patients with exacerbation of moderate–to–severe asthma. Special questionnaires (AQLQ, SGRQ) were used for this purpose. All patients with asthma exacerbation had lower quality of life compared to health subjects. After treatment, in 17–24 days, mean total scores were higher but scores of physical and psychological domains were lower than those in moderate asthma patients. Before discharge from the hospital, quality of life was inversely related to duration of disease. The study revealed that achieving a good control of asthma is associated not only to an improvement in asthma symptoms and the respiratory function but to significant increase in quality of life as well.